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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T8987 | Epiblastin A | Casein Kinase | |
Epiblastin A is an inhibitor of Casein Kinase 1 (CK1). Epiblastin A engages CK1 isoenzymes in cell lysate and induces efficient conversion of epiblast stem cells (EpiSCs) into embryonic stem cells (cESCs). | |||
T16695 | Pyrintegrin | Integrin | |
Pyrintegrin is an β1-integrin agonist that promotes embryonic stem cells' survival. Pyrintegrin can be used as a podocyte-protective agent. Pyrintegrin enhances cell-extracellular matrix adhesion-mediated integrin signal... | |||
T2161 | Cardiogenol C | Wnt/beta-catenin | |
Cardiogenol C is a cardiomyogenesis inducer in embryonic stem cells. | |||
T21981 | Phthalazinone pyrazole | Aurora Kinase | |
Phthalazinone pyrazole is potent, selective, and orally bioavailable inhibitor of Aurora-A kinase. Aurora-A is overexpressed in a variety of tumor types and displays oncogenic activity. | |||
T8005 | Cardiogenol C hydrochloride | Cardiogenol C HCl,Cardiogenol C | Wnt/beta-catenin |
Cardiogenol C hydrochloride (Cardiogenol C) can induces the differentiation of ESCs into cardiomyocytes (EC50= 100 nM). | |||
T3221 | Oct3/4-inducer-1 | 2-(4-(4-methoxybenzyloxy)phenyl)acetonitrile | Others , OCT |
Oct3/4-inducer-1 (2-(4-(4-methoxybenzyloxy)phenyl)acetonitrile) is an OCT3/4 inducer that promotes the expression and stabilization of OCT3/4 and enhances its transcriptional activity in a variety of human cells. | |||
T11469 | GSK-3484862 | DNA Methyltransferase | |
GSK-3484862 is a non-covalent Dnmt1 inhibitor. It induces DNA hypomethylation to against cancer. | |||
T3162 | IDE1 | Others | |
IDE1 can induce definitive endoderm from embryonic stem cells. It has been shown to induce the differentiation of Sox17+/FoxA2+-expressing pancreatic progenitors from human and mouse embryonic stems cells (EC50: 125.5 nM... | |||
T2019 | OAC2 | OCT | |
OAC2 is an Oct4 activator which activates expression through the Oct4 gene promoter; enhances reprogramming efficiency by increasing the rate of production of induced pluripotent stem cells (iPSCs) from embryonic fibrobl... | |||
T28866 | Stemazole | Apoptosis | |
Stemazole is a novel small molecule human stem/progenitor cell proliferation activator that promotes the survival of human embryonic stem cells and maintains stemness, and promotes the survival of oligodendrocyte precurs... | |||
T60143 | MitoBloCK-6 | Apoptosis | |
MitoBloCK-6 is a potent Erv1/ALR inhibitor, with an IC 50 of 900 nM and 700 nM, respectively. MitoBloCK-6 also inhibits Erv2 with IC 50 of 1.4 μM. MitoBloCK-6 can induce apoptosis via cytochrome c release in human embryo... | |||
T2310 | CHIR-99021 | Laduviglusib,CT99021,CHIR-99021 | GSK-3 , Wnt/beta-catenin , Autophagy |
CHIR-99021 (CT99021) is an activator of the Wnt/β-catenin signaling pathway and a GSK-3α/β inhibitor (IC50=10/6.7 nM) with selective and oral activity.CHIR-99021 induces cellular autophagy, which enhances self-renewal in... | |||
T2301 | SB 202190 | FHPI,SB202190 | Apoptosis , p38 MAPK , Autophagy |
SB 202190 (FHPI) is a p38 MAPK inhibitor that inhibits p38α and p38β2 (IC50=50/100 nM) selectively and cell-permeably. SB 202190 has antitumor activity and also induces the differentiation of human embryonic stem cells i... | |||
T3637 | Pifithrin-β hydrobromide | Cyclic PFT-α,PFT-β,Cyclic Pifithrin-α hydrobromide,Pifithrin-β,PFT β (hydrobromide) | Ferroptosis , p53 |
Pifithrin-β hydrobromide (Cyclic PFT-α) is an inhibitor of p53; reversibly blocks p53-dependent transcriptional activation and apoptosis. Protects against neuronal death in models of stroke and neurodegenerative disorder... | |||
T2310L | CHIR-99021 HCl | CT99021 HCl,Laduviglusib HCl | GSK-3 |
CHIR-99021 HCl (Laduviglusib HCl) is a highly potent and selective inhibitor of GSK-3α/β, with IC50 values of 10 nM and 6.7 nM respectively. It demonstrates remarkable selectivity for GSK-3, with over 500-fold selectivit... | |||
T70520 | TWS-119 | ||
TWS-119 is an inhibitor of glycogen synthase kinase-3β (GSK-3β) that induces neuronal differentiation in pluripotent murine embryonal carcinoma cells and embryonic stem cells (ESCs). | |||
T35549 | Elsinochrome A | ||
Elsinochrome A is a perylenequinone fungal metabolite that has been found inHypomycesand has anticancer activity.1Photoactivation of elsinochrome A induces the production of singlet oxygen and apoptosis in R366.4 rhesus ... | |||
T35561 | MS351 | ||
MS351 is an antagonist of chromobox 7 (CBX7) that acts by binding the CBX7 chromodomain. It enhances the binding of long noncoding RNA to the CBX7 chromodomain when used at 25 μM. MS351 induces transcriptional derepressi... | |||
T69743 | MEDS433 | ||
MEDS433 is a dihydroorotate dehydrogenase inhibitor (IC50 1.2 nM). MEDS433 inhibited the in vitro replication of hCoV-OC43 and hCoV-229E, as well as of SARS-CoV-2, at low nanomolar range. Notably, the anti-SARS-CoV-2 act... | |||
T75661 | Thymopentin acetate | ||
Thymopentin acetate, primarily secreted by the epithelial cells of the thymic cortex and medulla, serves as an effective immunomodulatory agent. It possesses a short plasma half-life of 30 seconds and significantly enhan... |